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Tumor lysis syndrome may be defined as a group of metabolic disorders which can result following treatment of cancer, commonly lymphomas and leukemias. It might sometimes occur even without treatment. This condition is characterized by the presence of hyperphosphatemia, hypocalcemia, hyperkalemia, and hyperuricemia following induction chemotherapy of malignant neoplasms. It is believed to be due to the release of intracellular products by cell lysis.
Induction chemotherapy is use of chemotherapy as initial treatment before surgery or radiotherapy of a malignancy. Hence, this is of great importance especially to the oncologists and radiation therapists. The biochemical changes which take place due to the metaolic disturbances in the case of tumour lysis syndrome may ultimately lead to acute uric acid nephropathy and acute renal failure.
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