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Sphingolipids is defined as a class of lipids which contain a long-chain base, which is simila to backbone of sphingoid bases, a set of aliphatic amino alcohols like that of sphingosine. They were discovered in the extracts of brain in the 1870s and because of their enigmatic nature were named for the mythological Sphinx. These compounds play important roles in transmission of signal and recognition of cell.
Sphingolipidoses, which is a disorder of metabolism of sphingolipid, have specific effect on nervous tissue. A sphingolipid with an R group, which consists of only a single hydrogen atom is called a ceramide. Other common R groups include phosphocholine, which yield a sphingomyelin, and different sugar monomers or dimers, which yield cerebrosides and globosides, respectively. Glycosphingolipids is a collective term for Cerebrosides and globosides. Sphingolipids like ceramides, cerebrosides, gangliosides and sphingomyelins are a constituent of nervous tissue.
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