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The chemotherapeutic drugs can be broadly classified into alkylating agents, like Cisplatin and carboplatin; antimetabolites, like purines((azathioprine, mercaptopurine)) or pyrimidines; plant alkaloids, like vinca alkaloids (like vincristine)and taxanes; topoisomerase inhibitors, like etoposide; and cytotoxic antibiotics like anthracyclines and actinomycin. The basic mechanism of action of these drugs is by impairing cell division or synthesis of DNA resulting in the destruction of cell. That's why the other name of these chemotherapeutic drugs is cytotoxic drugs.
The commonest route of administration of these chemotherapeutic drugs is intravenous, although some of these can also be administered orally like busulfan. Depending on the stage of the cancer and extent of the metastases, it is the oncologist who decides the route of administration, the drug, the dosage etc. It is a fact that chemotherapeutic drugs are not tolerated well by most patients. Some of the common side effects include anaemia, thrombocytopenia and infections resulting from decreased blood cell production; nausea and vomiting due to damage of the inner mucosa of the digestive tract; hair loss, etc.
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