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Cardiac markers are defined as biological markers which are measured to evaluate the function of heart. They are commonly discussed in connection with myocardial infarction, but other medical conditions can also result in an elevated cardiac marker level. Majority of the early markers which were identified happened to be enzymes, and therefore, the term cardiac enzymes is sometimes used to refer to these markers. However, all of the markers in current use are not enzymes.For example, troponin cannot be considered as a cardiac enzyme.
Elevated troponin is diagnostic of acute infarction, heart failure and myocarditis. Creatine Kinase: CK-MB test, an elevated level suggests infarct, but cannot be used in the late diagnosis of myocardial infarction. Lactate dehydrogenizes, but this is not so specific when compared with troponin. A high LDH-1 level to LDH-2 suggests myocardial infarction. Other cardiac markers include Aspartame transaminase (AST, myoglobin, ischemia-modified albumin (IMA) and pro-brain natriuretic peptide. Depending on the marker, it usually takes between 2 to 24 hours for an elevated level in the blood. Hence, these cardiac markers are not very useful in the diagnosis of an acute myocardial infarction.
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